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 Home > Product > Media > Microtechniques > SynVitro Cumulase
SynVitro®Cumulase™
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SynVitro®Cumulase™ is used for the removal (denudation) of the cell complex
(cumulus and corona radiata) surrounding the oocyte in preparation for ICSI.
Background
Prior to the ICSI procedure, the cells of the cumulus and corona radiata must be
removed in order to facilitate access to the oocyte and minimise contamination of
the injection needle.
SynVitro®Cumulase™ is the only ready-to-use recombinant human hyaluronidase
(rHuPH20) on the market. In contrast to the conventional animal hyaluronidase extracts,
SynVitro®Cumulase™ carries a number of advantages:
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Features |
Benefits |
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Less toxic than best available hyaluronidases
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Higher pregnancy rates due to less physical stress, as less mechanical stripping
is necessary
Exposure time is not critical
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Human origin of enzyme
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Human enzyme for human oocytes
No risk of any viral transmissions and other contaminant problems related to crude
animal extracts
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Free of any serum components or animal derivatives
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Unparalleled in purity and safety
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Ready-to-use single-cycle vials
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Convenient packaging preventing dilution and pipetting
Risk of contamination is eliminated
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8 weeks of shelf life
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Minimises media wastage
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Clinical data
Dr. Peter Nagy, USA presented clinical data at ESHRE 2005, where a bovine-derived
hyaluronidase extract was compared to Cumulase™. Data showed higher embryo
score on day 3 and higher fertilisation rates by using Cumulase™.
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Embryo score
Day 3
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Bovine
(competitor product)
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CumulaseTM
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26 patients
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Bovine
(competitor product)
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CumulaseTM
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Excellent
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44%
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61%
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Oocytes
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203
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199
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Good
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33%
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29%
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No. of fertilised oocytes
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146
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162
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Adequate
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5%
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4%
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Fertilisation rate
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71.9%
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81.4%
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Poor
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18%
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6%
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Increase in fertilisation rate
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-
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+13%
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Ref: Nagy et al.,Hum. Rep. 20 suppl.1, 2005, O-213
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Ref: Press release, June 22, 2005 </ www.halozyme.com?>www.halozyme.com
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Package Info
| Description |
Cat. No. |
Size |
Min. shelf life |
| Description |
Cat. No. |
Size |
Min. shelf life |
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SynVitro®Cumulase® |
15123000 |
3x0.5 ml |
12 weeks |
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